講座名稱：The Next Frontier: Engineering Magnetotheranostics for Magnetic Particle Imaging

講座人：Jeff W.M. Bulte 教授

講座時間：9月12日10:00-12:00

講座地點：會議中心104

講座人介紹：

Jeff W.M. Bulte博士是約翰·霍普金斯大學醫學院放射學、腫瘤學、生物醫學工程以及化學與生物分子工程教授。他是首任科學傳播放射學主任，并擔任約翰·霍普金斯細胞工程研究所細胞成像主任。他是ISMRM院士及金牌獲得者，WMIS、AIMBE和IAMBE院士，以及放射學研究院杰出研究員。他已發表350多篇論文和書籍章節，被引用超過4萬次。他的研究方向是開發新型造影劑和納米診療技術，并將其應用于分子和細胞成像，尤其側重于體內細胞追蹤和再生醫學。

講座內容：

Magnetic nanoparticles, including those formed of superparamagnetic iron oxides (SPIOs), are employed in various magnetic imaging and therapeutic techniques. In vivo imaging techniques include magnetic resonance imaging (MRI), magneto-motive ultrasonography (MMUS), magneto-photoacoustic imaging (MPAI), and magnetic particle imaging (MPI). An early example of magnetotheranostics are magnetically labeled therapeutic cells , i.e., immune cells for immunotherapy or stem cells for stem cell therapy, that can visualize their target after homing through trophic signaling, hereby also providing a diagnostic tool. More recently, the field of stem cell therapy has shifted towards “cell-free” therapy after recognizing that many of the active biomolecules are released by extracellular vesicles (EVs). Similar to their parental cells, EVs can be tracked in vivo after proper magnetic labeling, offering diagnostic information on for instance sites of inflammation in addition to exerting immunosuppresive therapeutic effects . Our lab and others have been exploring MPI to not only visualize the dynamic homing processes but also to provide quantative information using MPI “cytometry” and “EVmetry”.

A recent development in MPI-guided therapy has been the use of magnetotheranostics for magnetic fluid hyperthermia (MFH) or, when combined with gold nanoparticles, for photothermal therapy (PTT) . This has been demonstrated to be feasible not only for naked nanoparticles but also for labeled stem cells that can carry the nanoparticles towards the tumor for subsequent heating. Preclinical data indicate that the physical conditions required to heat up magnetic nanoparticles, including energy considerations, particle modifications, localization, and exposure time, can be dynamically modulated during a single treatment procedure by monitoring imaging data acquired from the same magnetic nanoparticles. This allows to selectively and precisely heat tumor locations while avoiding damage to surrounding healthy tissue, providing individualized treatment plans based on information about the biodistribution of magnetic nanoparticles within the tumor and adjacent organs, as well as the volumetric distribution of the thermal dose.

主辦單位：生命科學技術學院